347698
Which of the following statements is incorrect about gene therapy in ADA deficiency?
1 Patient does not require periodic infusion of genetically engineered lymphocytes.
2 Lymphocytes are then introduced in the body of patient.
3 A functional ADA cDNA using a retroviral vector is introduced into these lymphocytes.
4 Lymphocytes from patients' blood are taken out and cultured.
Explanation:
In gene therapy, lymphocytes from the blood of patient are grown in culture outside body. Later a functional ADA cDNA is introduced in lymphocytes which are returned in patients body. The cells are immortal and hence patient requires periodic infusion of genetically engineered lymphocytes.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347701
In gene therapy of Adenosine Deaminase (ADA) deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because:
1 Gene isolated from marrrow cells producing ADA is introduced into cells at embryonic stages.
2 Lymphocytes from patient's blood are grown in culture, outside the body.
3 Genetically engineered lumphocytes are not immortal cells.
4 Retroviral vector is introduced into these lymphocytes.
Explanation:
In gene therapy of ADA deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because they are not immortal cells.
NEET - 2022
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347702
In order for gene therapy to be most effective, genes should be inserted in?
1 WBC
2 RBC
3 Stem cells
4 All the above
Explanation:
In order for gene therapy to be most effective, genes should be inserted in stem cells- cells from which all other cells with specialized functions are generated.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347703
For the first time, gene therapy was tried on a 4 year old girl to treat which of the following enzyme deficiency in the year _?
1 Deoxyadenosine Aminase, 1983
2 Adenosine Deaminase, 1990
3 Adenosine Deaminase, 1983
4 Deoxyadenosine Aminase, 1990
Explanation:
For the first time in 1990, M Blease and WF Andresco of National Institute of Health, attempted gene therapy on a 4 year old girl with Adenosine Deaminase(ADA) deficiency. ADA deficiency is caused due to the deletion of gene for adenosine deaminase.
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BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347698
Which of the following statements is incorrect about gene therapy in ADA deficiency?
1 Patient does not require periodic infusion of genetically engineered lymphocytes.
2 Lymphocytes are then introduced in the body of patient.
3 A functional ADA cDNA using a retroviral vector is introduced into these lymphocytes.
4 Lymphocytes from patients' blood are taken out and cultured.
Explanation:
In gene therapy, lymphocytes from the blood of patient are grown in culture outside body. Later a functional ADA cDNA is introduced in lymphocytes which are returned in patients body. The cells are immortal and hence patient requires periodic infusion of genetically engineered lymphocytes.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347701
In gene therapy of Adenosine Deaminase (ADA) deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because:
1 Gene isolated from marrrow cells producing ADA is introduced into cells at embryonic stages.
2 Lymphocytes from patient's blood are grown in culture, outside the body.
3 Genetically engineered lumphocytes are not immortal cells.
4 Retroviral vector is introduced into these lymphocytes.
Explanation:
In gene therapy of ADA deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because they are not immortal cells.
NEET - 2022
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347702
In order for gene therapy to be most effective, genes should be inserted in?
1 WBC
2 RBC
3 Stem cells
4 All the above
Explanation:
In order for gene therapy to be most effective, genes should be inserted in stem cells- cells from which all other cells with specialized functions are generated.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347703
For the first time, gene therapy was tried on a 4 year old girl to treat which of the following enzyme deficiency in the year _?
1 Deoxyadenosine Aminase, 1983
2 Adenosine Deaminase, 1990
3 Adenosine Deaminase, 1983
4 Deoxyadenosine Aminase, 1990
Explanation:
For the first time in 1990, M Blease and WF Andresco of National Institute of Health, attempted gene therapy on a 4 year old girl with Adenosine Deaminase(ADA) deficiency. ADA deficiency is caused due to the deletion of gene for adenosine deaminase.
347698
Which of the following statements is incorrect about gene therapy in ADA deficiency?
1 Patient does not require periodic infusion of genetically engineered lymphocytes.
2 Lymphocytes are then introduced in the body of patient.
3 A functional ADA cDNA using a retroviral vector is introduced into these lymphocytes.
4 Lymphocytes from patients' blood are taken out and cultured.
Explanation:
In gene therapy, lymphocytes from the blood of patient are grown in culture outside body. Later a functional ADA cDNA is introduced in lymphocytes which are returned in patients body. The cells are immortal and hence patient requires periodic infusion of genetically engineered lymphocytes.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347701
In gene therapy of Adenosine Deaminase (ADA) deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because:
1 Gene isolated from marrrow cells producing ADA is introduced into cells at embryonic stages.
2 Lymphocytes from patient's blood are grown in culture, outside the body.
3 Genetically engineered lumphocytes are not immortal cells.
4 Retroviral vector is introduced into these lymphocytes.
Explanation:
In gene therapy of ADA deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because they are not immortal cells.
NEET - 2022
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347702
In order for gene therapy to be most effective, genes should be inserted in?
1 WBC
2 RBC
3 Stem cells
4 All the above
Explanation:
In order for gene therapy to be most effective, genes should be inserted in stem cells- cells from which all other cells with specialized functions are generated.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347703
For the first time, gene therapy was tried on a 4 year old girl to treat which of the following enzyme deficiency in the year _?
1 Deoxyadenosine Aminase, 1983
2 Adenosine Deaminase, 1990
3 Adenosine Deaminase, 1983
4 Deoxyadenosine Aminase, 1990
Explanation:
For the first time in 1990, M Blease and WF Andresco of National Institute of Health, attempted gene therapy on a 4 year old girl with Adenosine Deaminase(ADA) deficiency. ADA deficiency is caused due to the deletion of gene for adenosine deaminase.
347698
Which of the following statements is incorrect about gene therapy in ADA deficiency?
1 Patient does not require periodic infusion of genetically engineered lymphocytes.
2 Lymphocytes are then introduced in the body of patient.
3 A functional ADA cDNA using a retroviral vector is introduced into these lymphocytes.
4 Lymphocytes from patients' blood are taken out and cultured.
Explanation:
In gene therapy, lymphocytes from the blood of patient are grown in culture outside body. Later a functional ADA cDNA is introduced in lymphocytes which are returned in patients body. The cells are immortal and hence patient requires periodic infusion of genetically engineered lymphocytes.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347701
In gene therapy of Adenosine Deaminase (ADA) deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because:
1 Gene isolated from marrrow cells producing ADA is introduced into cells at embryonic stages.
2 Lymphocytes from patient's blood are grown in culture, outside the body.
3 Genetically engineered lumphocytes are not immortal cells.
4 Retroviral vector is introduced into these lymphocytes.
Explanation:
In gene therapy of ADA deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because they are not immortal cells.
NEET - 2022
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347702
In order for gene therapy to be most effective, genes should be inserted in?
1 WBC
2 RBC
3 Stem cells
4 All the above
Explanation:
In order for gene therapy to be most effective, genes should be inserted in stem cells- cells from which all other cells with specialized functions are generated.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347703
For the first time, gene therapy was tried on a 4 year old girl to treat which of the following enzyme deficiency in the year _?
1 Deoxyadenosine Aminase, 1983
2 Adenosine Deaminase, 1990
3 Adenosine Deaminase, 1983
4 Deoxyadenosine Aminase, 1990
Explanation:
For the first time in 1990, M Blease and WF Andresco of National Institute of Health, attempted gene therapy on a 4 year old girl with Adenosine Deaminase(ADA) deficiency. ADA deficiency is caused due to the deletion of gene for adenosine deaminase.