347743
The first human hormone produced by recombinant DNA technology is
1 Estrogen
2 Insulin
3 Progesterone
4 Thyroxin
Explanation:
In 1983, Eli lilly an American company prepared two DNA sequences corresponding to \(\mathrm{A}\) and \(\mathrm{B}\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains. Chains A and B were produced separately, extracted and combined by creating disulphide bonds to form human insulin.
AIPMT - 2014
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347744
Assertion : Hirudin is a protein that prevents blood clotting Reason : Gene encoding "Hirudin" is transferred into Brassica napus where hirudin is accumulated in the seeds
1 Both Assertion and Reason are correct and Reason is the correct explanation of the Assertion.
2 Both Assertion and Reason are correct but Reason is not the correct explanation of the Assertion.
3 Assertion is correct but Reason is incorrect.
4 Both Assertion and Reason are incorrect.
Explanation:
Hirudin is a protein that prevents blood clotting. Its gene was chemically synthesized and was transferred into Brassica napus where hirudin accumulates in seeds. The hirudin is extracted and purified and then used as medicine.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347745
Statement A : The two polypeptide chains are interconnected by disulphide bridges Statement B : In mammals including humans, insulin is synthesised as a prohormone, which contains an extra stretch called the C-peptide
1 Statement A is correct but Statement B is incorrect.
2 Statement A is incorrect but Statement B is correct.
3 Both statements are correct.
4 Both Statements are incorrect.
Explanation:
Two peptide chains as referred to \(A\) and B chains are linked together by two disulfide bonds while the additional disulfide is created within the A Chain. Hence, we can say that two polypeptides of human insulin are linked together by Disulfide bridges. In mammals, including humans, insulin is synthesised as pro-hormone which needs to be processed before it becomes a fully mature and functional hormone. It contains an extra stretch called the \(\mathrm{C}\) peptide which is removed during maturation into insulin. Both statements are correct.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347747
What is true about insulin?
1 It can be administered orally to diabetics
2 Insulin from animals may not elicit an immune response in human body
3 In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to A and B chains of human insulin and introduced them in plasmids of E. coli to produce insulin chains.
4 Insulin cannot be produced by G.M. bacteria as they are prokaryotic
Explanation:
In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to \(A\) and \(B\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains.
347743
The first human hormone produced by recombinant DNA technology is
1 Estrogen
2 Insulin
3 Progesterone
4 Thyroxin
Explanation:
In 1983, Eli lilly an American company prepared two DNA sequences corresponding to \(\mathrm{A}\) and \(\mathrm{B}\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains. Chains A and B were produced separately, extracted and combined by creating disulphide bonds to form human insulin.
AIPMT - 2014
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347744
Assertion : Hirudin is a protein that prevents blood clotting Reason : Gene encoding "Hirudin" is transferred into Brassica napus where hirudin is accumulated in the seeds
1 Both Assertion and Reason are correct and Reason is the correct explanation of the Assertion.
2 Both Assertion and Reason are correct but Reason is not the correct explanation of the Assertion.
3 Assertion is correct but Reason is incorrect.
4 Both Assertion and Reason are incorrect.
Explanation:
Hirudin is a protein that prevents blood clotting. Its gene was chemically synthesized and was transferred into Brassica napus where hirudin accumulates in seeds. The hirudin is extracted and purified and then used as medicine.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347745
Statement A : The two polypeptide chains are interconnected by disulphide bridges Statement B : In mammals including humans, insulin is synthesised as a prohormone, which contains an extra stretch called the C-peptide
1 Statement A is correct but Statement B is incorrect.
2 Statement A is incorrect but Statement B is correct.
3 Both statements are correct.
4 Both Statements are incorrect.
Explanation:
Two peptide chains as referred to \(A\) and B chains are linked together by two disulfide bonds while the additional disulfide is created within the A Chain. Hence, we can say that two polypeptides of human insulin are linked together by Disulfide bridges. In mammals, including humans, insulin is synthesised as pro-hormone which needs to be processed before it becomes a fully mature and functional hormone. It contains an extra stretch called the \(\mathrm{C}\) peptide which is removed during maturation into insulin. Both statements are correct.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347747
What is true about insulin?
1 It can be administered orally to diabetics
2 Insulin from animals may not elicit an immune response in human body
3 In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to A and B chains of human insulin and introduced them in plasmids of E. coli to produce insulin chains.
4 Insulin cannot be produced by G.M. bacteria as they are prokaryotic
Explanation:
In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to \(A\) and \(B\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains.
347743
The first human hormone produced by recombinant DNA technology is
1 Estrogen
2 Insulin
3 Progesterone
4 Thyroxin
Explanation:
In 1983, Eli lilly an American company prepared two DNA sequences corresponding to \(\mathrm{A}\) and \(\mathrm{B}\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains. Chains A and B were produced separately, extracted and combined by creating disulphide bonds to form human insulin.
AIPMT - 2014
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347744
Assertion : Hirudin is a protein that prevents blood clotting Reason : Gene encoding "Hirudin" is transferred into Brassica napus where hirudin is accumulated in the seeds
1 Both Assertion and Reason are correct and Reason is the correct explanation of the Assertion.
2 Both Assertion and Reason are correct but Reason is not the correct explanation of the Assertion.
3 Assertion is correct but Reason is incorrect.
4 Both Assertion and Reason are incorrect.
Explanation:
Hirudin is a protein that prevents blood clotting. Its gene was chemically synthesized and was transferred into Brassica napus where hirudin accumulates in seeds. The hirudin is extracted and purified and then used as medicine.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347745
Statement A : The two polypeptide chains are interconnected by disulphide bridges Statement B : In mammals including humans, insulin is synthesised as a prohormone, which contains an extra stretch called the C-peptide
1 Statement A is correct but Statement B is incorrect.
2 Statement A is incorrect but Statement B is correct.
3 Both statements are correct.
4 Both Statements are incorrect.
Explanation:
Two peptide chains as referred to \(A\) and B chains are linked together by two disulfide bonds while the additional disulfide is created within the A Chain. Hence, we can say that two polypeptides of human insulin are linked together by Disulfide bridges. In mammals, including humans, insulin is synthesised as pro-hormone which needs to be processed before it becomes a fully mature and functional hormone. It contains an extra stretch called the \(\mathrm{C}\) peptide which is removed during maturation into insulin. Both statements are correct.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347747
What is true about insulin?
1 It can be administered orally to diabetics
2 Insulin from animals may not elicit an immune response in human body
3 In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to A and B chains of human insulin and introduced them in plasmids of E. coli to produce insulin chains.
4 Insulin cannot be produced by G.M. bacteria as they are prokaryotic
Explanation:
In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to \(A\) and \(B\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains.
NEET Test Series from KOTA - 10 Papers In MS WORD
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BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347743
The first human hormone produced by recombinant DNA technology is
1 Estrogen
2 Insulin
3 Progesterone
4 Thyroxin
Explanation:
In 1983, Eli lilly an American company prepared two DNA sequences corresponding to \(\mathrm{A}\) and \(\mathrm{B}\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains. Chains A and B were produced separately, extracted and combined by creating disulphide bonds to form human insulin.
AIPMT - 2014
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347744
Assertion : Hirudin is a protein that prevents blood clotting Reason : Gene encoding "Hirudin" is transferred into Brassica napus where hirudin is accumulated in the seeds
1 Both Assertion and Reason are correct and Reason is the correct explanation of the Assertion.
2 Both Assertion and Reason are correct but Reason is not the correct explanation of the Assertion.
3 Assertion is correct but Reason is incorrect.
4 Both Assertion and Reason are incorrect.
Explanation:
Hirudin is a protein that prevents blood clotting. Its gene was chemically synthesized and was transferred into Brassica napus where hirudin accumulates in seeds. The hirudin is extracted and purified and then used as medicine.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347745
Statement A : The two polypeptide chains are interconnected by disulphide bridges Statement B : In mammals including humans, insulin is synthesised as a prohormone, which contains an extra stretch called the C-peptide
1 Statement A is correct but Statement B is incorrect.
2 Statement A is incorrect but Statement B is correct.
3 Both statements are correct.
4 Both Statements are incorrect.
Explanation:
Two peptide chains as referred to \(A\) and B chains are linked together by two disulfide bonds while the additional disulfide is created within the A Chain. Hence, we can say that two polypeptides of human insulin are linked together by Disulfide bridges. In mammals, including humans, insulin is synthesised as pro-hormone which needs to be processed before it becomes a fully mature and functional hormone. It contains an extra stretch called the \(\mathrm{C}\) peptide which is removed during maturation into insulin. Both statements are correct.
BIOXII12: BIOTECHNOLOGY AND ITS APPLICATIONS
347747
What is true about insulin?
1 It can be administered orally to diabetics
2 Insulin from animals may not elicit an immune response in human body
3 In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to A and B chains of human insulin and introduced them in plasmids of E. coli to produce insulin chains.
4 Insulin cannot be produced by G.M. bacteria as they are prokaryotic
Explanation:
In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to \(A\) and \(B\), chains of human insulin and introduced them in plasmids of E.coli to produce insulin chains.
