286303
Assertion: Insulin stimulates glycogenolysis and gluconeogenesis resulting in hyperglycemia.
Reason: Prolonged hyperglycemia leads to complex disorder called diabetes mellitus.
1 Both (A) and (R) are correct but (R) is not the correct explanation of$\left( A \right)$
2 (A) is correct but (R) is not correct
3 (A) is not correct but$\left( R \right)$ is correct
4 Both (A) and (R) are correct and (R) is the correct explanation of$\left( A \right)$
Explanation:
(c) Insulin plays a major role in the regulation of glucose homeostasis. Insulin mainly acts on hepatocytes and adipocytes (cells of adipose tissue), and enhances cellular glucose uptake and utilisation. As a result, there is a rapid movement of glucose from blood to hepatocytes and adipocytes resulting in decreased blood glucose level (hypoglycemia). Insulin stimulates conversion of glucose to glycogen (glycogenesis) in the target cells. Glucagon is a hyperglycemic hormone. Glucagon acts mainly on the liver cells (hepatocytes) and stimulates glycogenolysis which also contributes to a complex disorder called diabetes mellitus.
